6-oxohexanoate dehydrogenase

In enzymology, a 6-oxohexanoate dehydrogenase (EC 1.2.1.63) is an enzyme that catalyzes the chemical reaction

6-oxohexanoate NADP H₂O ${\displaystyle \rightleftharpoons }$ adipate NADPH 2 H

The 3 substrates of this enzyme are 6-oxohexanoate, NADP , and H₂O, whereas its 3 products are adipate, NADPH, and H .

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is 6-oxohexanoate:NADP oxidoreductase. This enzyme participates in caprolactam degradation.

References

• Davey JF, Trudgill PW (1977). "The metabolism of trans-cyclohexan-1,2-diol by an Acinetobacter species". Eur. J. Biochem. 74 (1): 115–27. doi:10.1111/j.1432-1033.1977.tb11373.x. PMID 856571.
• Donoghue NA, Trudgill PW (1975). "The metabolism of cyclohexanol by Acinetobacter NCIB 9871". Eur. J. Biochem. 60 (1): 1–7. doi:10.1111/j.1432-1033.1975.tb20968.x. PMID 1261.